Impact of Spices on Micronutrients, Phenolic Compounds, in Vitro and in Vivo Antioxidant Potentialities in Eggplant Leaves Cooked with Water
Kouamé-Osnou Cica Etoile,
Agbo Adouko Edith,
Gbogbo Moussa,
Gbogouri Grodji Albarin
Issue:
Volume 11, Issue 2, March 2023
Pages:
37-45
Received:
1 April 2023
Accepted:
20 April 2023
Published:
10 May 2023
Abstract: Eggplant leaves (Solanum macrocarpon) are rich in nutrients which are unfortunately lost during cooking. To reduce micronutrients losses and enhance antioxidant potentialities, they were cooked in water for 30 minutes with onion, ginger and Guinea pepper. The analyzes focused on the determination of vitamin C, β-carotene, phenolic compounds, free radical-scavenging and lipid peroxidation inhibitory activities. In Wistar rats, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) and glutathione peroxidase activities were also evaluated during 1 month. The results indicated that vitamin C remained low in eggplant leaves cooked with onion and spices. Cooked eggplant market leaves β-carotene content (187.11 μg/100 FM) increase from 447.43 μg/100 FM (with onion) to 905.44 μg/100 FM (with Guinea pepper). Ginger, Guinea pepper and onion improved eggplant field leaves free radical scavenging activities, which previous IC50 value (12.00 µg/ml) became 0.67, 0.83 and 3.08 μg/ml respectively. TBARS rate increased only for rats which received eggplant market leaves cooked with onion from 0.02 to 0.03 nmol/ml. SOD activities increased during the firsts 2 weeks of experiment. Glutathione peroxidase activities is high in serum of rats which received eggplant field leaves cooked with onion (18.70 nmol/min/ml). Onion, ginger and Guinea pepper enhance eggplant antioxidant potentialities during cooking.
Abstract: Eggplant leaves (Solanum macrocarpon) are rich in nutrients which are unfortunately lost during cooking. To reduce micronutrients losses and enhance antioxidant potentialities, they were cooked in water for 30 minutes with onion, ginger and Guinea pepper. The analyzes focused on the determination of vitamin C, β-carotene, phenolic compounds, free r...
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Computational Exploration of Vitis vinifera-Derived Molecules as SARS-CoV-2 Main Protease Inhibitors: A Quantum Chemical and Molecular Modeling Approach
Issue:
Volume 11, Issue 2, March 2023
Pages:
46-56
Received:
17 May 2023
Accepted:
2 June 2023
Published:
9 June 2023
Abstract: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has unleashed a global health crisis, resulting in an alarming number of cases exceeding 765 million and deaths surpassing 6 million as of March 2023. Consequently, researchers worldwide are dedicating their efforts to exploring potential drug candidates that can serve as effective therapeutic interventions against this devastating virus. Meanwhile, the popularity of herbal medicines is skyrocketing, as individuals increasingly seek alternative remedies to address various health concerns within different healthcare systems around the world. In this study, a multitude of computational tools were employed to meticulously investigate the Vitis Vinifera extracts for their potential as inhibitors of the SARS-CoV-2 Mpro enzyme. These tools encompassed molecular docking, binding energy calculation, ADMET studies as well as quantum chemical calculations. The objective was to identify specific compounds present in Vitis Vinifera extracts that could effectively hinder the activity of the SARS-CoV-2 Mpro enzyme, a crucial target for therapeutic intervention. The rigorous analysis conducted unveiled six compounds that demonstrated significant potential as inhibitors of the SARS-CoV-2 Mpro enzyme: Hyperoside, Gallocatechin gallate, cis-Astringin, peonidin-3-O-glucoside, Fraxin, and cis-Piceid. When compared to the established standard drug Nelfinavir, these compounds exhibited superior binding affinities and slightly improved ADMET properties. Notably, peonidin-3-O-glucoside emerged as an especially promising compound, surpassing the others as well as the standard drug in terms of binding energy, reactivity, and stability. These findings suggest its potential as a potent inhibitor of the SARS-CoV-2 Mpro enzyme. However, it is imperative to emphasize that further validation through in vivo and in vitro studies is indispensable. While the computational results provide valuable insights, their practical application necessitates verifying the efficacy and safety of these compounds.
Abstract: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has unleashed a global health crisis, resulting in an alarming number of cases exceeding 765 million and deaths surpassing 6 million as of March 2023. Consequently, researchers worldwide are dedicating their efforts to exploring potential drug candidates that can serve as effective therapeutic ...
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