Hepatitis B is a viral infection of liver caused by a virus from the Hepadnavirus family. It’s a public health problem in sub-Saharan Africa and particularly in Côte d'Ivoire where it is poorly documented. This study's contribution to biological databases was significant. It aimed to establish the biochemical and viral load (VL) profile of hepatitis B in a population of blood donors infected with hepatitis B virus (HBV) and naïve to antiretroviral treatment in Abidjan. It was a descriptive cross-sectional study of voluntary blood donors of any sex, with a positive result for HBsAg and naive of any antiretroviral therapy. Venous blood samples of 4 ml were collected for biochemical marker determinations, quantitative antigen, and PCR VL. A questionnaire was also used to collect socio-demographic data from study participants The National Ethics Committee for Life Sciences and Health in Cote d'Ivoire granted its approval for the study (N/Réf: 196-22/MSHPCMU/CNESVS-km). 53 voluntary blood donors infected with HBV (HBsAg positive) were included in the study. 81.13% of participants were men. The average age of all participants was 35 ± 9 years, and the predominant age group was 30 to 40 (35.85%). Transaminase values were normal in 98.57% of the study population for ASAT and 96.23% for ALAT. Creatinine was normal in 90.57% of volunteers. Total proteidaemia, natremia, and kalemia were below normal in respectively 86.79%, 73.58% and 20.75% of this population. Quantitative HBsAg were high in 24.53% of the population. Viral load was elevated in 9.43% of patients. There was a significant association between increased VL in log and increased uremia. There was also a significant association between the increase in the amount of HBs antigen and the number of copies of the virus. The study noted a renal and hepatic balance without particularity. The ion balance was disrupted, and about a quarter of the study population had high values of quantitative HBs antigenemia. The VL was high in about one-tenth of the volunteers.
| Published in | American Journal of BioScience (Volume 11, Issue 6) |
| DOI | 10.11648/j.ajbio.20231106.14 |
| Page(s) | 159-163 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Hepatitis B, Biochemistry Markers, Viral Load, Quantitative Antigen
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APA Style
Samuel, D. E., Claude, L. E., Eugene, M. K., Philippe, N. J., Philippe, K. S., et al. (2023). Profile of Biochemical Markers and Viral Load in a Population of Blood Donors Infected with Hepatitis B and Naive Antiretroviral Treatment in Abidjan. American Journal of BioScience, 11(6), 159-163. https://doi.org/10.11648/j.ajbio.20231106.14
ACS Style
Samuel, D. E.; Claude, L. E.; Eugene, M. K.; Philippe, N. J.; Philippe, K. S., et al. Profile of Biochemical Markers and Viral Load in a Population of Blood Donors Infected with Hepatitis B and Naive Antiretroviral Treatment in Abidjan. Am. J. BioScience 2023, 11(6), 159-163. doi: 10.11648/j.ajbio.20231106.14
AMA Style
Samuel DE, Claude LE, Eugene MK, Philippe NJ, Philippe KS, et al. Profile of Biochemical Markers and Viral Load in a Population of Blood Donors Infected with Hepatitis B and Naive Antiretroviral Treatment in Abidjan. Am J BioScience. 2023;11(6):159-163. doi: 10.11648/j.ajbio.20231106.14
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Download@article{10.11648/j.ajbio.20231106.14,
author = {Doukou Essien Samuel and Lohoues Esmel Claude and Messou Kouassi Eugene and N’din Jean-Louis Philippe and Kambou Sansan Philippe and Mamadou Sekongo and Tiahou Gnomblesson Georges},
title = {Profile of Biochemical Markers and Viral Load in a Population of Blood Donors Infected with Hepatitis B and Naive Antiretroviral Treatment in Abidjan},
journal = {American Journal of BioScience},
volume = {11},
number = {6},
pages = {159-163},
doi = {10.11648/j.ajbio.20231106.14},
url = {https://doi.org/10.11648/j.ajbio.20231106.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20231106.14},
abstract = {Hepatitis B is a viral infection of liver caused by a virus from the Hepadnavirus family. It’s a public health problem in sub-Saharan Africa and particularly in Côte d'Ivoire where it is poorly documented. This study's contribution to biological databases was significant. It aimed to establish the biochemical and viral load (VL) profile of hepatitis B in a population of blood donors infected with hepatitis B virus (HBV) and naïve to antiretroviral treatment in Abidjan. It was a descriptive cross-sectional study of voluntary blood donors of any sex, with a positive result for HBsAg and naive of any antiretroviral therapy. Venous blood samples of 4 ml were collected for biochemical marker determinations, quantitative antigen, and PCR VL. A questionnaire was also used to collect socio-demographic data from study participants The National Ethics Committee for Life Sciences and Health in Cote d'Ivoire granted its approval for the study (N/Réf: 196-22/MSHPCMU/CNESVS-km). 53 voluntary blood donors infected with HBV (HBsAg positive) were included in the study. 81.13% of participants were men. The average age of all participants was 35 ± 9 years, and the predominant age group was 30 to 40 (35.85%). Transaminase values were normal in 98.57% of the study population for ASAT and 96.23% for ALAT. Creatinine was normal in 90.57% of volunteers. Total proteidaemia, natremia, and kalemia were below normal in respectively 86.79%, 73.58% and 20.75% of this population. Quantitative HBsAg were high in 24.53% of the population. Viral load was elevated in 9.43% of patients. There was a significant association between increased VL in log and increased uremia. There was also a significant association between the increase in the amount of HBs antigen and the number of copies of the virus. The study noted a renal and hepatic balance without particularity. The ion balance was disrupted, and about a quarter of the study population had high values of quantitative HBs antigenemia. The VL was high in about one-tenth of the volunteers.
},
year = {2023}
}
TY - JOUR T1 - Profile of Biochemical Markers and Viral Load in a Population of Blood Donors Infected with Hepatitis B and Naive Antiretroviral Treatment in Abidjan AU - Doukou Essien Samuel AU - Lohoues Esmel Claude AU - Messou Kouassi Eugene AU - N’din Jean-Louis Philippe AU - Kambou Sansan Philippe AU - Mamadou Sekongo AU - Tiahou Gnomblesson Georges Y1 - 2023/12/08 PY - 2023 N1 - https://doi.org/10.11648/j.ajbio.20231106.14 DO - 10.11648/j.ajbio.20231106.14 T2 - American Journal of BioScience JF - American Journal of BioScience JO - American Journal of BioScience SP - 159 EP - 163 PB - Science Publishing Group SN - 2330-0167 UR - https://doi.org/10.11648/j.ajbio.20231106.14 AB - Hepatitis B is a viral infection of liver caused by a virus from the Hepadnavirus family. It’s a public health problem in sub-Saharan Africa and particularly in Côte d'Ivoire where it is poorly documented. This study's contribution to biological databases was significant. It aimed to establish the biochemical and viral load (VL) profile of hepatitis B in a population of blood donors infected with hepatitis B virus (HBV) and naïve to antiretroviral treatment in Abidjan. It was a descriptive cross-sectional study of voluntary blood donors of any sex, with a positive result for HBsAg and naive of any antiretroviral therapy. Venous blood samples of 4 ml were collected for biochemical marker determinations, quantitative antigen, and PCR VL. A questionnaire was also used to collect socio-demographic data from study participants The National Ethics Committee for Life Sciences and Health in Cote d'Ivoire granted its approval for the study (N/Réf: 196-22/MSHPCMU/CNESVS-km). 53 voluntary blood donors infected with HBV (HBsAg positive) were included in the study. 81.13% of participants were men. The average age of all participants was 35 ± 9 years, and the predominant age group was 30 to 40 (35.85%). Transaminase values were normal in 98.57% of the study population for ASAT and 96.23% for ALAT. Creatinine was normal in 90.57% of volunteers. Total proteidaemia, natremia, and kalemia were below normal in respectively 86.79%, 73.58% and 20.75% of this population. Quantitative HBsAg were high in 24.53% of the population. Viral load was elevated in 9.43% of patients. There was a significant association between increased VL in log and increased uremia. There was also a significant association between the increase in the amount of HBs antigen and the number of copies of the virus. The study noted a renal and hepatic balance without particularity. The ion balance was disrupted, and about a quarter of the study population had high values of quantitative HBs antigenemia. The VL was high in about one-tenth of the volunteers. VL - 11 IS - 6 ER -
Care, Research and Training Center (CePReF), Abidjan, Côte d’Ivoire
Biochemistry Laboratory of Medical Sciences Department, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire
Care, Research and Training Center (CePReF), Abidjan, Côte d’Ivoire
Biochemistry Laboratory of Medical Sciences Department, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire; Center Integrated of Research Bioclinical of Abidjan (CIRBA), Abidjan, Côte d’Ivoire
Biochemistry Laboratory of Medical Sciences Department, Félix Houphouët-Boigny University, Abidjan, Côte d’Ivoire
National Blood Transfusion Centre of Abidjan (CNTS), Abidjan, Côte d’Ivoire
Biochemistry Laboratory of Medical Sciences Department, Alassane Ouattara University, Bouake, Côte d’Ivoire
