American Journal of BioScience

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Molecular Diagnosis of Rickettsia aeschlimannii in Febrile Patients in Côte d’Ivoire

Received: 26 September 2023    Accepted: 24 October 2023    Published: 9 November 2023
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Abstract

R aeschlimannii is a bacterium that causes Mediterranean spotted fever. It is a rickettsial disease, which is an acute febrile illness characterized by the appearance of skin pimples and bedsores. R. aeschlimannii is mainly transmitted by ticks of the genus Hyalomma, which are present throughout the African continent, including Côte d’Ivoire. Despite the presence of the pathogen and its potential vectors in Côte d'Ivoire, the disease is not yet well-known or even undiagnosed in our health centers. Consequently, it is a neglected disease. The aim of this study is to search for R. aeschlimannii bacteria in febrile patients in order to improve the management of febrile illnesses in Côte d’Ivoire. Blood samples taken from patients to test for yellow fever virus and stored in the Institut Pasteur of Côte d’Ivoire biobank were also used to test for R. aeschlimannii by quantitative PCR. The 5 to 14-year-olds patients from Korhogo were infested with R. aeschlimannii with a relatively low prevalence of 9.10%. Our results underline the need to continue the study to control certain tick-borne diseases transmitted to both animals and humans. In the north of the country, the age group most vulnerable to Mediterranean spotted fever is the pre-adolescent age.

DOI 10.11648/j.ajbio.20231106.11
Published in American Journal of BioScience (Volume 11, Issue 6, November 2023)
Page(s) 137-141
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Rickettsia aeschlimannii, Mediterranean Spotted Fever, Ticks, Febrile Patients, Côte d’Ivoire

References
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[2] Combes C. 1995. Interections durables. Ecologie et évolution du parasitisme, Edition Masson, France. 524p.
[3] Diobo F. N., Yao P. K., Diaha K. A. C. A., Adjogoua V. E., Faye H. K. 2021. Detection of Rickettsia africae in ticks and cattle in Côte d'Ivoire by real-time PCR. Journal of Applied Biosciences, 166: 17242–17251.
[4] Djerbouh A., Tahar K., Assia B., Socolovschi C., Kechemir N., Parola P., Raoult D., Bitam I. 2012. The first molecular detection of Rickettsia aeschlimannii in the ticks of camels from southern Algeria. Ticks and Tick-borne Diseases, 3: 373–375.
[5] Ehounoud C. B., Yao K. P., Dahmani M., Yaba L. A., Amanzougaghene N., Douba A. K. 2016. Multiple Pathogens Including Potential New Species in Tick Vectors in Côte d'Ivoire. PLOS Neglected Tropical Diseases, 10 (1): 1-18.
[6] Frean J. Grayson W. 2019. South African Tick Bite Fever: An Overview. Dermatopathology, 6: 70–76.
[7] Germanakis A., Chochlakis D., Angelakis E., Tselentis Y., Psaroulaki A. 2013. Rickettsia aeschlimannii infection in a man, Greece. Emerging Infectious Diseases, 19 (7): 1176-1177.
[8] Kleinerman G., Baneth G., Mumcuoglu K. Y., Straten M., Berlin D., Apanaskevich D. A., Abdeen Z., Nasereddin A., Harrus S., 2013. Molecular detection of Rickettsia africae, Rickettsia aeschlimannii and Rickettsia sibirica mongolitimonae in camels and Hyalomma spp. ticks from Israel. Vector Borne Zoonotic Diseases, 13: 851–856.
[9] Luce-Fedrow A., Mullins K., Kostik A. P., St John H. K., Jiang J., Richards A. L. 2015. Strategies for detecting rickettsiae and diagnosing rickettsial diseases. Future microbiology, 10 (4): 537-564.
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[11] Mouffok N., Parola P., Abdennour D., Aouati A., Razik F., Benabdellah A., Raoult D., 2009. Mediterranean spotted fever in Algerian children. Clinical Microbiology Infectious, 15 (2): 290–291.
[12] Mura A., Socolovschi C., Ginesta J., Lafrance B., Magnan S., Rolain J. M., Davoust B., Raoult D., Parola P., 2008. Molecular detection of spotted fever group rickettsiae in ticks from Ethiopia and Chad. Transactions of the Royal Society of Tropical Medicine and Hygiene. 102: 945–949.
[13] Parola P., Paddock C. D., Socolovschi C., Labruna M. B., Mediannikov O., Kernif T., 2013. Update on tickborne rickettsioses around the world: a geographic approach. Clinical Microbiology Reviews, 26 (4): 657–702.
[14] Raoult D., Fournier P. E., Abboud P., Caron F., 2002. First documented human Rickettsia aeschlimannii infection. Emerging. Infectious Diseases, 8: 748–749.
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  • APA Style

    Diobo, F. N., Diaha, A. C. A. K., Sylla, Y., Bogni, G. R., Adjogoua, V. E., et al. (2023). Molecular Diagnosis of Rickettsia aeschlimannii in Febrile Patients in Côte d’Ivoire. American Journal of BioScience, 11(6), 137-141. https://doi.org/10.11648/j.ajbio.20231106.11

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    ACS Style

    Diobo, F. N.; Diaha, A. C. A. K.; Sylla, Y.; Bogni, G. R.; Adjogoua, V. E., et al. Molecular Diagnosis of Rickettsia aeschlimannii in Febrile Patients in Côte d’Ivoire. Am. J. BioScience 2023, 11(6), 137-141. doi: 10.11648/j.ajbio.20231106.11

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    AMA Style

    Diobo FN, Diaha ACAK, Sylla Y, Bogni GR, Adjogoua VE, et al. Molecular Diagnosis of Rickettsia aeschlimannii in Febrile Patients in Côte d’Ivoire. Am J BioScience. 2023;11(6):137-141. doi: 10.11648/j.ajbio.20231106.11

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  • @article{10.11648/j.ajbio.20231106.11,
      author = {Fidèle N’guessan Diobo and Amenan Claude Aimée Kouamé Diaha and Yahaya Sylla and Grace Rebecca Bogni and Valery Edgard Adjogoua and Hortense Kette Faye and Mireille Dosso and Patrick Kouassi Yao},
      title = {Molecular Diagnosis of Rickettsia aeschlimannii in Febrile Patients in Côte d’Ivoire},
      journal = {American Journal of BioScience},
      volume = {11},
      number = {6},
      pages = {137-141},
      doi = {10.11648/j.ajbio.20231106.11},
      url = {https://doi.org/10.11648/j.ajbio.20231106.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20231106.11},
      abstract = {R aeschlimannii is a bacterium that causes Mediterranean spotted fever. It is a rickettsial disease, which is an acute febrile illness characterized by the appearance of skin pimples and bedsores. R. aeschlimannii is mainly transmitted by ticks of the genus Hyalomma, which are present throughout the African continent, including Côte d’Ivoire. Despite the presence of the pathogen and its potential vectors in Côte d'Ivoire, the disease is not yet well-known or even undiagnosed in our health centers. Consequently, it is a neglected disease. The aim of this study is to search for R. aeschlimannii bacteria in febrile patients in order to improve the management of febrile illnesses in Côte d’Ivoire. Blood samples taken from patients to test for yellow fever virus and stored in the Institut Pasteur of Côte d’Ivoire biobank were also used to test for R. aeschlimannii by quantitative PCR. The 5 to 14-year-olds patients from Korhogo were infested with R. aeschlimannii with a relatively low prevalence of 9.10%. Our results underline the need to continue the study to control certain tick-borne diseases transmitted to both animals and humans. In the north of the country, the age group most vulnerable to Mediterranean spotted fever is the pre-adolescent age.
    },
     year = {2023}
    }
    

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    AU  - Fidèle N’guessan Diobo
    AU  - Amenan Claude Aimée Kouamé Diaha
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    AU  - Grace Rebecca Bogni
    AU  - Valery Edgard Adjogoua
    AU  - Hortense Kette Faye
    AU  - Mireille Dosso
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    AB  - R aeschlimannii is a bacterium that causes Mediterranean spotted fever. It is a rickettsial disease, which is an acute febrile illness characterized by the appearance of skin pimples and bedsores. R. aeschlimannii is mainly transmitted by ticks of the genus Hyalomma, which are present throughout the African continent, including Côte d’Ivoire. Despite the presence of the pathogen and its potential vectors in Côte d'Ivoire, the disease is not yet well-known or even undiagnosed in our health centers. Consequently, it is a neglected disease. The aim of this study is to search for R. aeschlimannii bacteria in febrile patients in order to improve the management of febrile illnesses in Côte d’Ivoire. Blood samples taken from patients to test for yellow fever virus and stored in the Institut Pasteur of Côte d’Ivoire biobank were also used to test for R. aeschlimannii by quantitative PCR. The 5 to 14-year-olds patients from Korhogo were infested with R. aeschlimannii with a relatively low prevalence of 9.10%. Our results underline the need to continue the study to control certain tick-borne diseases transmitted to both animals and humans. In the north of the country, the age group most vulnerable to Mediterranean spotted fever is the pre-adolescent age.
    
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Author Information
  • Biology and Health Laboratory, Felix Houphouët-Boigny University, Abidjan, Côte d’Ivoire; Vector-Borne Virus Unit, Institute Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire

  • Environment and Health Department, Institute Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire

  • Vector-Borne Virus Unit, Institute Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire

  • Biology and Health Laboratory, Felix Houphouët-Boigny University, Abidjan, Côte d’Ivoire

  • Vector-Borne Virus Unit, Institute Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire

  • Genital Tract Agents Unit, Institute Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire

  • Bacteriology Virology Department, Institute Pasteur of Côte d’Ivoire, Abidjan, Côte d’Ivoire

  • Animal Parasitology Laboratory, Alassane Ouattara University, Bouaké, Côte d'Ivoire

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